Cross-talk between transforming growth factor-β and Wingless/Int pathways in lung development and disease |
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| Authors: | Parviz Minoo Changgong Li |
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| Institution: | 1. Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;2. Martini-Clinic, Prostate Cancer Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;3. Division of Theoretical Bioinformatics, German Cancer Research Center, Heidelberg, Germany;4. Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany;5. Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany;3. Departments of Pathobiology, Cleveland Clinic Foundation, Cleveland, Ohio 44195;4. Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294;6. Pulmonary and Critical Care Division and Department of Medicine, University of California, San Francisco, California 94143;5. Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94158;1. Department of Genitourinary Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia;2. Department of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Monash Partners Comprehensive Cancer Consortium, Monash University, Melbourne, Australia;3. The Sir Peter MacCallum Department of Oncology, University of Melbourne, Australia;1. Department of Respiratory Medicine, Tokyo Medical University Ibaraki Medical Center, 3-20-1 Chuou, Ami-machi, Inashiki-gun, Ibaraki 300-0395, Japan;2. Respiratory Medicine, Institute of Geriatrics Tokyo Women’s Medical University, 2-15-1 Shibuya, Shibuya-ku, Tokyo 150-0002, Japan |
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| Abstract: | Lung development depends on accurate and precise patterning of a pulmonary anlagen, consisting of both endodermally and mesodermally derived progenitor cells. In this process, the need to establish communication and control among individual cells is paramount. Transforming growth factor-β (TGFβ) and Wingless/int (Wnt) signaling pathways serve this need. The individual functional repertoire of the two pathways is further expanded by cross-talk and integration of signaling at multiple levels taking advantage of their hard-wired multi-component signal transduction platforms. Cross-talk creates the possibility for both specificity and versatility in signaling during development and during repair of injured tissue. Understanding the mechanics and the physiological implications of this cross-talk is necessary for therapeutic or preventive targeting of either TGFβ or Wnt signaling pathways. |
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