Comparative in vivo expression of amastigote up regulated Leishmania genes in three different forms of Leishmaniasis |
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| Authors: | Paresh Sharma Srividya Gurumurthy Robert Duncan Hira L Nakhasi Poonam Salotra |
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| Institution: | 1. Department of Medical Microbiology, Faculty of Emine-Bahaeddin Nak?boglu Medicine, University of Zirve, ?ahinbey, Gaziantep 27260, Turkey;2. Department of Parasitology, Faculty of Medicine, University of Cukurova, Balcali, Saricam, Adana 01330, Turkey;3. Department of Pediatrics, Faculty of Medicine, University of Cukurova, Balcali, Saricam, Adana 01330, Turkey;4. Department of Dermatology, Faculty of Medicine, University of Akdeniz, Konyaalti, Antalya 07070, Turkey;5. Department of Dermatology, Faculty of Medicine, University of Cukurova, Balcali, Saricam, Adana 01330, Turkey |
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| Abstract: | In Old World Leishmania infections in India, Leishmania donovani is responsible for visceral leishmaniasis (VL) and post kala-azar dermal leishmaniasis (PKDL) while L. tropica is responsible for cutaneous leishmaniasis (CL) in humans. The molecular differences between the two species of Leishmania and within the same species causing distinct pathologies that govern the outcome of infection and pathogenesis in the human host are unknown. Quantitative expression of selected genes was evaluated directly in lesion tissues of VL, PKDL and CL patients. Assessment of in vivo mRNA level highlighted substantial differences in gene expression patterns, providing an indication of the genes involved in pathogenesis in the three different forms of Leishmaniasis. |
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