Technical methods to improve yield,activity and stability in the development of microbial lipases |
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Authors: | Zheng-Yu Shu Huan Jiang Rui-Feng Lin Yong-Mei Jiang Lin Lin Jian-Zhong Huang |
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Institution: | 1. Engineering Research Center of Industrial Microbiology, Ministry of Education, Fujian Normal University, Fuzhou, Fujian 350108, PR China;2. College of Life Sciences, Fujian Normal University, Fuzhou, Fujian 350108, PR China;3. Engineering Research Center of Fujian Modern Fermentation Technology, Fuzhou, Fujian 350108, PR China |
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Abstract: | Lipases are ubiquitous biocatalysts that catalyze various reactions in organic solvents or in solvent-free systems and are increasingly applied in various industrial fields. In view of the excellent catalytic activities and the huge application potential, more than 20 microbial lipases have been realized in large-scale commercial production. The potential for commercial exploitation of a microbial lipase is determined by its yield, activity, stability and other characteristics. This review will survey the various technical methods that have been developed to enhance yield, activity and stability of microbial lipases from four aspects, including improvements in lipase-producing strains, modification of lipase genes, fermentation engineering of lipases and downstream processing technology of lipase products. |
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