The Number of Proliferating Cells in the Rostral Migratory Stream of Rat During the First Postnatal Month |
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| Authors: | Marcela Martončíková Enikő Račeková Judita Orendáčová |
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| Institution: | (1) Institute of Neurobiology, Center of Excellence, Slovak Academy of Sciences, Šoltésovej 4, 04001 Košice, Slovak Republic |
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| Abstract: | SUMMARY The objective of this study was to analyze neurogenesis in the rat rostral migratory stream (RMS) during the first postnatal month.1. During the early postnatal development some morphological changes, concerning the RMS thickness, shape, and the olfactory ventricle persistence at P0 were observed.2. Bromodeoxyuridine (BrdU) immunohistochemistry and subsequent quantification of proliferating cells showed significant age-dependent changes. The highest number of proliferating cells was found at P3 and significant decrease of BrdU-positive cells at P7 rats. At P28, the number of proliferating cells reached the level of P0 rats. |
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| Keywords: | rostral migratory stream early postnatal development cell proliferation quantitative analysis BrdU immunohistochemistry |
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