The Tape Measure Protein of the Staphylococcus aureus Bacteriophage vB_SauS-phiIPLA35 Has an Active Muramidase Domain |
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| Authors: | Rodríguez-Rubio Lorena Gutiérrez Dolores Martínez Beatriz Rodríguez Ana Götz Friedrich García Pilar |
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| Institution: | Instituto de Productos Lácteos de Asturias (IPLA-CSIC), Department of Technology and Biotechnology of Dairy Products, Asturias, Spain. |
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| Abstract: | Tailed double-stranded DNA (dsDNA) bacteriophages frequently harbor structural proteins displaying peptidoglycan hydrolytic activities. The tape measure protein from Staphylococcus aureus bacteriophage vB_SauS-phiIPLA35 has a lysozyme-like and a peptidase_M23 domain. This report shows that the lysozyme-like domain (TG1) has muramidase activity and exhibits in vitro lytic activity against live S. aureus cells, an activity that could eventually find use in the treatment of infections. |
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