The impact of E-cadherin expression on non-small cell lung cancer survival: a meta-analysis |
| |
Authors: | Ying Wu Hong-Bing Liu Ming Ding Jian-Nan Liu Ping Zhan Xiao-Su Fu Gan Lu |
| |
Affiliation: | Department of Respiratory Medicine, Jiangsu Province Geriatric Hospital, Jiangsu Province Geriatric Institute, 30 Luojia Road, Nanjing, 210024, China. |
| |
Abstract: | E-cadherin has been implicated in invasiveness and metastasis. However, the clinical prognostic value of decreased E-cadherin expression in patients with non-small cell lung cancer (NSCLC) remains unsettled. A meta-analysis of eligible studies was performed to quantitatively review the correlation of decreased E-cadherin expression with survival in patients with NSCLC. Thirteen studies, including 2,274 patients, were subjected to final analysis. The rate of decreased E-cadherin expression was 47.6?% overall and 41.4?% for stage I disease. The combined hazard ratio (HR) was 1.41 (95?% CI 0.18-1.65; P?=?0.001), indicating that decreased E-cadherin expression had an unfavorable impact on the survival of patients with NSCLC. Further, in the stratified analysis by ethnicity, the combined HR in Asians was 1.49 (95?% CI 1.27-1.71) and in non-Asians was 1.01 (95?% CI 1.00-1.02). However, when only the stage I studies were considered, the combined HR was 1.19 (95?% CI 0.90-1.47; P?=?0.576), suggesting that decreased E-cadherin expression has no impact on survival. Decreased E-cadherin expression was associated with poor survival in patients with NSCLC, especially among Asians, but was not significantly correlated with survival for stage I NSCLC patients. |
| |
Keywords: | |
本文献已被 PubMed SpringerLink 等数据库收录! |
|