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Dual Regulatory Functions of SUFU and Targetome of GLI2 in SHH Subgroup Medulloblastoma
Authors:Wen-Chi Yin  Thevagi Satkunendran  Rong Mo  Sorana Morrissy  Xiaoyun Zhang  Eunice Shiao Huang  Liis Uusküla-Reimand  Huayun Hou  Joe Eun Son  Weifan Liu  Yulu C Liu  Jianing Zhang  Jessica Parker  Xin Wang  Hamza Farooq  Hayden Selvadurai  Xin Chen  Elly Sau-Wai Ngan  Chi-chung Hui
Institution:1. Program in Developmental & Stem Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada;2. Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada;3. Arthur and Sonic Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada;4. Department of Biochemistry & Molecular Biology, University of Calgary, Calgary, AB, Canada;5. Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, AB, Canada;6. Alberta Children’s Hospital Research Institute, University of Calgary, Calgary, AB, Canada;7. Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada;8. Department of Biochemistry, University of Toronto, Toronto, ON, Canada;9. Joint Institute of Genetics and Genomic Medicine, Zhejiang University and University of Toronto, Toronto, ON, Canada;10. Department of Surgery, University of Hong Kong, Hong Kong SAR, China;11. Department of developmental Genetics, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China
Abstract:
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  • Keywords:medulloblastoma  Hedgehog signaling  SUFU  GLI2  SPOP  targetome  mouse model
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