Long-term feeding a high-fat diet causes histological and parasitological effects on murine schistosomiasis mansoni outcome |
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Authors: | Neves Renata Heisler Miranda de Barros Alencar Alba Cristina Costa-Silva Michele Aguila Márcia Barbosa Mandarim-de-Lacerda Carlos Alberto Machado-Silva José Roberto Gomes Delir Corrêa |
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Affiliation: | Laboratory of Helminthology Romero Lascasas Porto, Biomedical Center, Department of Pathology and Laboratories, Faculty of Medical Sciences, State University of Rio de Janeiro, Brazil. |
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Abstract: | This study investigated whether long-term feeding a high-fat diet (HFC) has an effect on schistosomiasis mansoni outcome compared to standard chow diet (SC). Swiss Webster female mice (3 wk old) fed each diet over 5 months, and then were infected with 50 Schistosoma mansoni cercariae. Their nutritional status was assessed by monitoring growth rates twice a week and measuring serum levels of lipoproteins. Mice were euthanised 63 days after infection. Parasitological and liver histological analyses were performed. The levels of TC, HDL-C and LDL-C, fecal and tissue schistosome eggs were statistically different (p<0.05) between groups. Livers from HFC mice showed exudative, exudative/exudative-productive, exudative-productive and productive granulomas, some degree of hepatic steatosis and focal necrosis. Mice fed normal-chow did not present productive granulomas and hepatic steatosis. The morphometric evaluation of hepatic granulomas did not reach statistical significance (p>0.05) between diets assayed. The high-fat diet for long-term produces effects on schistosomiasis mansoni outcome. |
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Keywords: | Schistosoma mansoni Experimental infection High-fat diet Parasitological study Granuloma |
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