Serum cholinesterase isoenzymes and the WHHL rabbit: the relationship between the activity of cholinesterase not bound to low-density-lipoprotein and lipoprotein titer |
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| Authors: | Celestine Udom Dennis Barnard Timothy Smith |
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| Affiliation: | (1) Center for Medical Education at Indiana State University, Indiana University School of Medicine, 47809 Indiana, Terre Haute;(2) Division of Research Resources, National Institutes of Health, 20892 Bethesda, Maryland, USA;(3) Department of Pharmacology and Toxicology, Center for Medical Education at Indiana State University, Indiana University School of Medicine, 47809 Terre Haute, IN, USA |
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| Abstract: | Summary Serum cholinesterase has been previously shown to complex with beta-lipoprotein in the plasma. Since serum cholinesterase exists as isoenzymes in plasma, the relationship between the activity of these isoenzymes (unbound to beta-lipoprotein) and lipoprotein titer was investigated. The results indicated that the total of C2, C3, and C4 isoenzyme activities were expressed within a narrow range and independent of low density lipoprotein titer. These findings may indicate that unbound plasma cholinesterase may undergo autoregulation independent of cholinesterase bound to beta-lipoprotein.Abbreviations WHHL rabbit Watanabe Heritable Hyperlipidemic rabbit - LDL low-density lipoprotein - VLDL very low-density lipoprotein - HDL high-density lipoprotein - C(1–4) serum cholinesterase isoenzyme (1–4) |
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| Keywords: | low-density-lipoprotein serum cholinesterase WHHL rabbit |
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