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Tazarotene-induced gene 1 inhibits prostaglandin E2-stimulated HCT116 colon cancer cell growth |
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| Authors: | Fu-Ming Tsai Chang-Chieh Wu Rong-Yaun Shyu Chun-Hua Wang Shun-Yuan Jiang |
| Institution: | (1) Department of Research, Buddhist Tzu Chi General Hospital Taipei Branch, 289 Jianguo Rd, Sindian District, New Taipei City, 231, Taiwan;(2) Department of Internal Medicine, Buddhist Tzu Chi General Hospital Taipei Branch, 289 Jianguo Rd, Sindian District, New Taipei City, 231, Taiwan;(3) Department of Dermatology, Buddhist Tzu Chi General Hospital Taipei Branch, 289 Jianguo Rd, Sindian District, New Taipei City, 231, Taiwan;(4) Department of Surgery, Tri-Service General Hospital, 325 Chengung Rd, Sec 2, Taipei, 114, Taiwan;(5) School of Medicine, Tzu Chi University, 701 Zhongyang Rd, Sec 3, Hualien, 970, Taiwan |
| Abstract: | BackgroundThe tazarotene-induced gene 1 (TIG1) is a putative tumor suppressor gene. We have recently demonstrated both TIG1A and TIG1B isoforms inhibited cell growth and induced the expression of G protein-coupled receptor kinase 5 (GRK5) in colon cancer cells. Because elevated prostaglandin E2 (PGE2) signaling plays a significant role in colorectal carcinogenesis, the objective of this study was to explore the effect of TIG1 on PGE2-induced cellular proliferation and signaling in colon cancer cells. |
| Keywords: | prostaglandin E2 TIG1 RARRES1 GRK5 β-catenin colon cancer |
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