Nitrogen regulation of erythromycin formation in Streptomyces erythreus |
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| Authors: | Ma.Elena Flores,Sergio Sá nchez |
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| Affiliation: | Escuela de Química, Universidad Autónoma del Estado de México, Mexico;Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, México, D.F. 04510, México |
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| Abstract: | Abstract Erythromycin formation decreased in Streptomyces erythreus as a function of the ammonium concentration present in the medium. Total inhibition of synthesis was obtained with 100 mM NH4Cl but medium pH and culture growth were not significantly affected. A similar effect was obtained with NH4NO3 or (NH4)2SO4 indicating that ammonium ion probably repressed formation of antibiotic. |
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| Keywords: | Erythromycin ammonium concentration |
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