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Lyt-1 cells mediate acute murine experimental allergic encephalomyelitis |
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| Authors: | S L Hauser H L Weiner A K Bhan M E Shapiro M Che W R Aldrich N L Letvin |
| Abstract: | Adult SJL/J mice were depleted of T lymphocytes and were reconstituted with Lyt-1, Lyt-2, or Lyt-1 + Lyt-2 cells. After immunization with MSCH, severe acute EAE developed in the Lyt-1- and the Lyt-1 + Lyt-2-reconstituted mice. Only 25% of the Lyt-2-reconstituted mice developed signs of EAE, and in those EAE onset was delayed. Thus, Lyt-1 cells mediate EAE in the mouse. |
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