Biosynthesis of delta-aminolevulinic acid in the unicellular rhodophyte, cyanidium caldarium. |
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| Authors: | J E Jurgenson S I Beale R F Troxler |
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| Institution: | 1. Medical Research Council Group in Molecular Endocrinology, Centre Hospitalier de l''Universite Laval, Quebec, G1V 4G2, Canada;2. Polypeptide Laboratories, V.A. Hospital, New Orleans, LA 70146 USA.;3. Tulane University School of Medicine, New Orleans, LA 70146 USA. |
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| Abstract: | Intravenous injection of sheep antiserum to somatostatin in the rat not only increases basal plasma TSH levels but also potentiates TSH response following exposure to cold (5° C). Plasma levels of GH rise 2–3 fold during the first 3 h after injection of the antiserum, with a progressive decrease of the effect up to 10 h. Rhythmical change of serum GH levels during a 10-hour period of observation is not altered after antiserum injection. These data indicate that somatostatin plays a physiological role in the control of both TSH and GH secretion and suggest the involvement of GH-releasing hormone, in addition to somatostatin, in the GH release mechanism. |
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| Keywords: | To whom reprint requests should be addressed |
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