The effects of chronic metabolic acidosis on patterns of protein synthesis in rat renal cortex

• 1.1. In the rat chronic metabolic acidosis increases the net synthesis of 17 renal cortex proteins by amounts ranging from 1.5 to 4.5-fold.
• 2.2. These proteins have molecular weights between 13,000 and 42,000 and isoelectric points between approximately 5.5 and 7.0.
• 3.3. No new proteins not also present in normal animals are detected in renal cortex samples from acidotic animals.
• 4.4. Three proteins undergo substantial reductions in their net synthetic rates in chronic metabolic acidosis.
• 5.5. On the basis of their physical properties and similar alterations in net synthetic rate in acidosis some of these proteins appear to be closely related and may be coordinately expressed in the rat kidney.