Differential effects of ibuprofen and naproxen sodium on menstrual prostaglandin release and on prostaglandin production in the rat uterine homogenate |
| |
| Affiliation: | 1. Bezmialem Vakif University, School of Medicine, Department of Pediatric Surgery, Istanbul, Turkey;2. Izmir Saglik Bilimleri University, Tepecik Training and Research Hospital, Department of Urology, Izmir, Turkey;3. Bezmialem Vakif University, School of Medicine, Department of Pathology, Istanbul, Turkey;4. Bezmialem Vakif University, Medical Laboratory Techniques Program, Istanbul, Turkey;5. Bezmialem Vakif University, School of Medicine, Department of Biochemistry, Istanbul, Turkey;6. Istanbul Medeniyet University, School of Medicine, Department of Pediatric Surgery, Istanbul, Turkey;7. Bezmialem Vakif University, School of Medicine, Istanbul, Turkey;8. Bezmialem Vakif University, Scgool of Medicine, Emergency Medicine, Istanbul, Turkey;1. Department of Pharmacology and toxicology, Faculty of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran;2. Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran;3. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran;4. Department of pediatrics, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran;5. Department of Occupational Health, Faculty of Health, Urmia University of Medical Sciences, Urmia, Iran;6. Department of Anatomy and Reproductive Biology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;7. Department of Obstetrics & Gynecology, School of Medicine, Urmia University of Medical Science, Urmia, Iran;8. Department of Anatomy, School of Medicine, Iran University of Medical Sciences, Tehran, Iran;9. Department of Pathology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran;10. Cardiovascular Division, Department of Medicine, Brigham and Women''s Hospital, Harvard Medical School, United States;11. Department of Toxicology-Pharmacology, Faculty of Pharmacy, Guilan University of Medical Sciences, Rasht, Iran;1. Department of Urology, School of Medicine, Marmara University, Istanbul, Turkey;2. Department of Pharmacology, School of Pharmacy, Marmara University, Istanbul, Turkey;3. Department of Biochemistry, School of Pharmacy, Cumhuriyet University, Sivas, Turkey;4. Department of Biochemistry, Faculty of Dentistry, Marmara University, Istanbul, Turkey;5. Department of Histology & Embryology, School of Medicine, Marmara University, Istanbul, Turkey;1. Department of Biochemical Engineering, Gangneung-Wonju National University, Gangwon 210-702, Republic of Korea;2. Division of Bioscience and Biotechnology, BMIC, Konkuk University, Seoul 143-701, Republic of Korea;3. Department of Biological Sciences, Konkuk University, Seoul 143-701, Republic of Korea;4. Department of Aquatic Life Medicine, Kunsan National University, Kunsan 573-701, Republic of Korea;1. Institute for Particle Technology, Volkmaroder Str. 5, 38104 Braunschweig, Germany;2. Institute for Pharmaceutical Technology, Mendelssohnstr. 1, 38106 Braunschweig, Germany;3. Novartis Pharma AG, 4002 Basel, Switzerland |
| |
| Abstract: | In two independent studies, ibuprofen and naproxen sodium were found to be equi-effective in alleviating dysmenorrheic symptoms. However, the effects of these drugs on menstrual PG release were found to be dissimilar. Ibuprofen primarily inhibited menstrual PGF2α release with little effect on PGE release, whereas, naproxen sodium inhibited both PGF2α and PGE2 release equally. To verify these results, we determined the inhibitory potency, IC 50' of ibuprofen and naproxen sodium on PGF2α and PGE2 synthesis in the rat uterine homogenate system. The preferential PGF2a inhibitory activity of ibuprofen was confirmed.These findings suggest that ibuprofen may, in addition to inhibiting fatty acid cyclooxygenase, also inhibit PGF2α reductase, or some other PG metabolic pathways which affect PGF a and PGE2 synthesis differently. The significance of this differential PG synthesis inhibitory effect in dysmenorrheic therapy is discussed. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
