| 免疫应答期间脑和淋巴器官中去甲肾上腺素含量的变化 |
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| 引用本文： | 彭聿平,李炳源.免疫应答期间脑和淋巴器官中去甲肾上腺素含量的变化[J].中国应用生理学杂志,1995,11(2):144-146. |
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| 作者姓名： | 彭聿平 李炳源 |
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| 作者单位： | 南通医学院生理学教研室，南通医学院中心实验室 |
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| 摘 要： | 应用高效液相色谱－电化学检测法（ＨＰＬＣ－ＥＣＤ）测定大鼠在用绵羊红细胞（ＳＲＢＣ）免疫后第２－７天期间，下丘脑、海马、脑干、胸腺和脾脏中去甲肾上腺素（ＮＡ）含量的变化。实验结果表明，下丘脑内ＮＡ含量在免疫后第４－７天明显增加，其中第７天有回降趋势。海马内ＮＡ含量在第４－５天显著增多。而胸腺和脾脏中ＮＡ水平在第４－５天均明显降低。脑干在免疫应答期间无明显改变。以上结果说明，体液免疫应答可影响脑和淋
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| 关 键 词： | 去甲肾上腺素 免疫应答 脑 淋巴器官 |
CHANGES OF NORADRENALINE CONTENT IN BRAIN AND LYMPHOID ORGANS DURING
IMMUNE RESPONSE |
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| Peng Yuping,Qiu Yihua,Zhang Qingquan,Li Bingyuan,Wang Jianhe.CHANGES OF NORADRENALINE CONTENT IN BRAIN AND LYMPHOID ORGANS DURING
IMMUNE RESPONSE[J].Chinese Journal of Applied Physiology,1995,11(2):144-146. |
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| Authors: | Peng Yuping Qiu Yihua Zhang Qingquan Li Bingyuan Wang Jianhe |
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| Abstract: | The changes of
noradrenaline(NA)content in hypothalamus,hippocampus,brainstem,thymus
and spleen of rats immunized with sheep red blood cells(SRBC)were
determined duringday 2 to 7 after immunization by means of
high-performance liquid chromatography withelectrochemical detection.
The NA concentration in hypothalamus markedly increased duringday 4
to 7 post-immunization, tending to recovery on day 7. The NA level
was high inhippocampus but was low in thymus and spleen during day 4
to 5 following SRBC injection ascompared with saline-injected control
animals. There was no significant change of NA content inbrainstem
during humoral immune response, These results indicate that humoral
immune re-sponse may affect the NA metabolism in brain and lymphoid
organs.In relating to our previousinvestigation that NA may influence
the proliferation of T lymphocytes,the data show the pres-ence of
interaction between NA and immune system. |
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| Keywords: | noradrenaline immune response hypothalamus hippocampus thymus spleen neuroimmunomodulation |
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