| 缺血预处理降低大鼠心室易颤性 |
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| 引用本文： | 沈岳良,黄德明.缺血预处理降低大鼠心室易颤性[J].中国应用生理学杂志,1995,11(2):140-143. |
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| 作者姓名： | 沈岳良 黄德明 |
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| 作者单位： | 浙江医科大学生理学教研室，浙江医科大学机能中心，香港大学医学院生理系 |
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| 摘 要： | 本实验应用离体大鼠Ｌａｎｇｅｎｄｏｒｆｆ灌流模型，研究模拟缺血预处理（ＩＰ）对心脏的保护作用。发现ＩＰ可引起心室颤动阈（ＶＦＴ）升高、心律失常发生率和严重程度降低、心室有效不应期短时延长。ＩＰ对心脏的保护作用在预缺血后３０ｍｉｎ已基本消失。提示ＩＰ对离体大鼠心肌有保护作用，且时间较为短暂。
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| 关 键 词： | 缺血预处理 心室颤动阈 心肌缺血 再灌注损伤 |
ISCHEMIC PRECONDITIONING DECREASES THE VENTRICULAR VULNERABILITY OF
THE RAT HEART |
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| Shen Yueliang,Xia Qiang,Lu Yuan,Luo
Jiangen.ISCHEMIC PRECONDITIONING DECREASES THE VENTRICULAR VULNERABILITY OF
THE RAT HEART[J].Chinese Journal of Applied Physiology,1995,11(2):140-143. |
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| Authors: | Shen Yueliang Xia Qiang Lu Yuan Luo
Jiangen |
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| Abstract: | The aim of the present study is to determine the cardioprotective
effect of ischemic. preconditioning and to explore whether or not
this effect is related to the decrease in myocardial vulnerability
and to the changes in effective refractory pe.In the isolated
Langendorff-perfused hearts of rats,the technique of global
ischemia-reperfusion was used.The results showed that ischemic
preconditioning increased the ventricular fibrillation
threshold,reduced the incidence and severity of spontaneous
arrhythmias and caused transient prolongation of the effective
refractory period during the sustained ischemia-reperfusion. The
beneficial action of ischemic preconditioning was lost following a 30
minute reperfusion period in the model.The results indicated that
ischemic preconditioning pro- tected myocardium against arrhythmia
induced by ischemia-reperfusion and this cardioprotective effect was
transient in the isolated rat heart. |
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| Keywords: | ischemic preconditioning ventricular fibrillation threshold arrhythmia |
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