Effect of ethanol on intracellular Ca2+ metabolism |
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Authors: | Babich L G Shlykov S G Borisova L A |
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Institution: | Palladin Institute of Biochemistry, National Academy of Science of Ukraine, Kyiv. |
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Abstract: | The aim of this review is to summarize current thinking on ethanol effects on the Ca2+ homeostasis in the excitable tissue cells. It has been shown that acute exposure to ethanol decreases cytoplasmic Ca2+ concentration due to Ca2+ channels inhibition and Ca2+ pumps activation. Whereas chronic exposure to ethanol increases the intracellular Ca2+ concentration in cells due to activation of passive Ca2+ transport systems and inhibition of energy-dependent Ca2+ transport systems. The emphasis is place on a possible role of pharmacologic agents that preserve Ca2+ homeostasis in protecting against ethanol-induced diseases. |
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