Driving proteins off DNA using applied tension. |
| |
| Authors: | J F Marko and E D Siggia |
| |
| Affiliation: | Department of Physics, The University of Illinois at Chicago, 60607-7059, USA. marko@isolda.phy.uic.edu |
| |
| Abstract: | Proteins that bind DNA so as to reduce its end-to-end length can be dissociated by application of force. The thermodynamics of this process are discussed, with special attention to the case of histones bound to DNA (i.e., a string of nucleosomes, or chromatin fiber). The histone octamer is predicted to be driven off chromatin fiber for tensions >2 piconewtons. |
| |
| Keywords: | |
|
|
