The effect of medial forebrain bundle lesion on thyrotropin secretion in the rat |
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Authors: | Abdullah Jaffer William M U Daniels Vivienne A Russell Joshua J F Taljaard |
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Institution: | (1) MRC Research Unit for the Neurochemistry of Mental Diseases, Department of Chemical Pathology, University of Stellenbosch, Tygerberg Hospital, P.O. Box 19113, 7505 Tygerberg, (R.S.A.) |
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Abstract: | The medial forebrain bundle (MFB) was partially lesioned with 6-hydroxydopamine (6-OHDA) in order to investigate the effect of deficient central noradrenergic regulation on thyrotropin (TSH) secretion in the rat. 6-OHDA injection into the MFB significantly reduced the noradrenaline (NA), dopamine (DA) and serotonin (5-HT) content of the whole hypothalamus. NA and 5-HT concentrations were also significantly decreased in the paraventricular nucleus (PVN). The MFB lesion did not affect the clonidine (250 g/kg, i.p.) induced stimulation of TSH release or the isoproterenol (1 mg/kg i.p.) induced decrease in TSH levels. Thyrotropin releasing hormone (TRH, 5 g/kg i.v.) caused a similar significant stimulation of TSH secretion in lesioned and non-lesioned rats. The present results do not support the hypothesis that the blunted TSH response to TRH observed in depressed patients results from a deficiency in noradrenergic neurotransmission. |
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Keywords: | Thyrotropin medial forebrain bundle 6-hydroxydopamine clonidine isoproterenol thyrotropin releasing hormone |
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