Lipid rafts and the control of neurotrophic factor signaling in the nervous system: variations on a theme |
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| Authors: | Paratcha Gustavo Ibáñez Carlos F |
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| Institution: | 1. Department of Surgery, Oregon Health and Science University, Portland, OR;2. Department of Pathology, Oregon Health and Science University, Portland, OR;3. Department of Vascular and Interventional Radiology, Oregon Health and Science University, Portland, OR;4. Division of Cardiac Surgery, Department of Surgery, Oregon Health and Science University, Portland, OR;5. Division of Vascular Surgery, Oregon Health and Science University, Portland, OR;1. Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, People''s Republic of China;2. Key Laboratory for Tropical Diseases Control, Sun Yat-sen University, Ministry of Education, Guangzhou 510080, People''s Republic of China;3. Department of Pathogen Biology, Hainan Medical College, Haikou, Hainan 571199, People''s Republic of China;4. School of Nursing, Guangdong Medical College, Dongguan 523808, People''s Republic of China;1. Cell and Molecular Physiology Department, Loyola University Chicago, Stritch School of Medicine, 2160 S. First Avenue, Maywood, IL 60153, USA;2. Office of Research Services, Loyola University Chicago, Stritch School of Medicine, 2160 S. First Avenue, Maywood, IL 60153, USA;3. Institute for Translational Neuroscience, Department of Lab Medicine & Pathology, University of Minnesota, Minneapolis, MN 55455, USA;4. Neuroscience Institute, Loyola University Chicago, Stritch School of Medicine, 2160 S. First Avenue, Maywood, IL 60153, USA;1. Department of Genetics-Research Unit, Institute of Ophthalmology “Conde de Valenciana”, Mexico City, Mexico;2. Medizinische Fakultät Mannheim, Universität Heidelberg, Mannheim, Germany;3. Department of Retina, Institute of Ophthalmology “Conde de Valenciana”, Mexico City, Mexico;4. Department of Genetics, Instituto Nacional de Rehabilitación, Mexico City, Mexico;5. Department of Biochemistry, Faculty of Medicine, UNAM, Mexico City, Mexico;1. Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea;2. Department of Medicine, Division of Cardiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea |
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| Abstract: | Lipid rafts are specialized, liquid-ordered subdomains of the plasma membrane. Through their ability to promote specific compartmentalization of lipids and membrane proteins, lipid rafts have emerged as membrane platforms specialized for signal transduction. In recent years, signaling by neurotrophic factors and their receptors has been shown to depend upon the integrity and function of lipid rafts and associated components. It has also been shown that these microdomains play critical roles in selective axon-dendritic sorting and the proteolytic processing of several neurotrophic ligands and receptors in neuronal cells. The available evidence supports an important role for lipid rafts in the initiation, propagation and maintenance of signal transduction events triggered by different neurotrophic factors and their receptors in the nervous system. |
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