Loss of E-cadherin promotes the growth,invasion and drug resistance of colorectal cancer cells and is associated with liver metastasis |
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Authors: | Xiaobing Chen Yongsheng Wang Hongping Xia Qiwu Wang Xiaochun Jiang Zihong Lin Yuedong Ma Yang Yang Minghua Hu |
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Institution: | (1) Henan Cancer Hospital, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, 450008, China;(2) Shanghai Pulmonary Hospital, Tongji University, Shanghai, 200433, China;(3) Department of Surgery, Yijishan Hospital, Wannan Medical College, Wuhu, 241001, China;(4) Chengdu Military General Hospital, Chengdu, 610083, China;(5) The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China; |
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Abstract: | The recent studies indicated that the epithelial cell adhesion molecule E-cadherin is a well-recognized molecule that is important
in cell adhesion. To further investigate the molecular basis of this notion, we used small-interfering RNA to inhibit E-cadherin
function and found that loss of E-cadherin promoted Colorectal cancer cell growth, invasion and drug resistance through induction
of β-catenin nuclear translocation and epithelial-to-mesenchymal transition. Further analysis of E-cadherin expression with
clinicopathologic parameters showed that E-cadherin expression decreased in Colorectal cancer patients who developed liver
metastasis (P = 0.043). These findings indicate that E-cadherin loss in tumors contributes to progression and metastatic dissemination.
Thus, E-cadherin can act as a central modulator of the cell biological phenotypes and a potential prognostic marker in Colorectal
cancer. |
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