BAR proteins in cancer and blood disorders |
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| Authors: | Yolande Chen Jorie Aardema Ashish Misra Seth J Corey |
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| Institution: | 1.Departments of Pediatrics and Cell & Molecular Biology, Children’s Memorial Hospital, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL;2.Division of Cardiology, Department of Medicine, Yale University School of Medicine, New Haven, CT, USA |
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| Abstract: | Remodeling of the membrane and cytoskeleton is involved in a wide range of normal and pathologic cellular function. These are complex, highly-coordinated biochemical and biophysical processes involving dozens of proteins. Serving as a scaffold for a variety of proteins and possessing a domain that interacts with plasma membranes, the BAR family of proteins contribute to a range of cellular functions characterized by membrane and cytoskeletal remodeling. There are several subgroups of BAR proteins: BAR, N-BAR, I-BAR, and F-BAR. They differ in their ability to induce angles of membrane curvature and in their recruitment of effector proteins. Evidence is accumulating that BAR proteins contribute to cancer cell invasion, T cell trafficking, phagocytosis, and platelet production. In this review, we discuss the physiological function of BAR proteins and discuss how they contribute to blood and cancer disorders. |
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| Keywords: | BAR proteins GTPases WASP blood cancer |
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