Age-related Differentiation in Newly Generated DCX Immunoreactive Neurons in the Subgranular Zone of the Gerbil Dentate Gyrus |
| |
| Authors: | In Koo Hwang Ki-Yeon Yoo Sun Shin Yi Young-Guen Kwon Young-Keun Ahn Je Kyung Seong In Se Lee Yeo Sung Yoon Moo-Ho Won |
| |
| Institution: | (1) Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul, 151-742, South Korea;(2) Department of Anatomy and Neurobiology, College of Medicine, Hallym University, Chuncheon, 200-702, South Korea;(3) Department of Biochemistry, College of Sciences, Yonsei University, Seoul, 120-749, South Korea;(4) The Heart Center of Chonnam National University Hospital, 8 Hak Dong, Dong Ku, Gwangju, 501-757, South Korea;(5) Institute of Neurodegeneration and Neuroregeneration, Hallym University, Chuncheon, 200-702, South Korea |
| |
| Abstract: | In the present study, we investigated age-related changes of newborn neurons in the gerbil dentate gyrus using doublecortin
(DCX), a marker of neuronal progenitors which differentiate into neurons in the brain. In the postnatal month 1 (PM 1) group,
DCX immunoreactivity was detected in the subgranular zone of the dentate gyrus, but DCX immunoreactive neurons did not have
fully developed processes. Thereafter, DCX immunoreactivity and its protein levels in the dentate gyrus were found to decrease
with age. Between PM 3 and PM 18, DCX immunoreactive neuronal progenitors showed well-developed processes which projected
to the granular layer of the dentate gyrus, but at PM 24, a few DCX immunoreactive neuronal progenitors were detected in the
subgranular zone of the dentate gyrus. DCX protein level in the dentate gyrus at PM 1 was high, thereafter levels of DCX were
decreased with time. The authors suggest that a decrease of DCX immunoreactivity and its protein level with age may be associated
with aging processes in the hippocampal dentate gyrus. |
| |
| Keywords: | Aging Dentate gyrus Neurogenesis Doublecortin Gerbil |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
