A mechanism for early branching in lung morphogenesis |
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Authors: | Sharon R. Lubkin J. D. Murray |
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Affiliation: | (1) Department of Applied Mathematics, University of Washington, Box 352420, 98195-2420 Seattle, WA, USA |
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Abstract: | The lung is a highly branched fluid-filled structure, that develops by repeated dichotomous branching of a single bud off the foregut, of epithelium invaginating into mesenchyme. Incorporating the known stress response of developing lung tissues, we model the developing embryonic lung in fluid mechanical terms. We suggest that the repeated branching of the early embryonic lung can be understood as the natural physical consequence of the interactions of two or more plastic substances with surface tension between them. The model makes qualitative and quantitative predictions, as well as suggesting an explanation for such observed phenomena as the asymmetric second branching of the embryonic bronchi. |
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Keywords: | Lung Pattern formation Morphogenesis Fetal development |
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