Carbohydrate metabolism in the rat peritoneal macrophages |
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Authors: | S K Bansal |
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Institution: | (1) Industrial Toxicology Research Centre, Mahatma Gandhi Marg, 226 001 Lucknow, India;(2) Present address: Central Research Station, G.S.V.M. Medical College, 208 002 Kanpur, India |
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Abstract: | Rat peritoneal macrophages derive energy differently from other tissues. Resting rat peritoneal macrophages have been taken
for the present investigation. Lactate produced by extracellular glycolysis in the peritoneal lavage fluid, is readily converted
into pyruvate by resting peritoneal macrophages and is oxidised in mitochondria. Glycolytic enzymes other than phosphoglucoisomerase
and lactate dehydrogenase could not be substantially demonstrated. Glucose-6-phosphate dehydrogenase was detected. The presence
of glucose-6-phosphate dehydrogenase along with phosphoglucoisomerase indicates the operation of the hexose monophosphate
shunt as a pathway supplementary to glycolysis. Resting rat peritoneal macrophages thus appear to utilize extracellular lactate
as their main energy source instead of glucose, bypass glycolysis and have active hexose monophosphate shunt. |
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Keywords: | Carbohydrate metabolism macrophage |
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