Cilostazol Attenuates Ovariectomy-Induced Bone Loss by Inhibiting Osteoclastogenesis |
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| Authors: | Ke Ke Ali Muhammad Safder Ok-Joo Sul Jae-Hee Suh Yeonsoo Joe Hun-Taeg Chung Hye-Seon Choi |
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| Institution: | 1Department of Biological Sciences, University of Ulsan, Ulsan 680–749, Korea;2Department of Pathology, Ulsan University Hospital, Ulsan 682–714, Korea;Faculté de médecine de Nantes, FRANCE |
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| Abstract: | BackgroundCilostazol has been reported to alleviate the metabolic syndrome induced by increased intracellular adenosine 3’,5’-cyclic monophosphate (cAMP) levels, which is also associated with osteoclast (OC) differentiation. We hypothesized that bone loss might be attenuated via an action on OC by cilostazol.Conclusions/SignificanceOur data highlight the therapeutic potential of cilostazol for attenuating bone loss and oxidative stress caused by loss of ovarian function. |
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