Chicken atrial natriuretic peptide (chANP) and its secretion |
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Authors: | Hirotaka Toshimori Kiyotaka Toshimori Naoto Minamino Kenji Kangawa Chikayoshi Oura Shigeru Matsukura Hisayuki Matsuo |
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Institution: | (1) Third Division of Internal Medicine, Miyazaki Medical College, Miyazaki, Japan;(2) Anatomy, Miyazaki Medical College, Miyazaki, Japan;(3) Biochemistry, Miyazaki Medical College, Miyazaki, Japan |
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Abstract: | Summary An immunohistochemical study using antiserum raised against synthetic chicken natriuretic polypeptide was used to investigate the distribution of this peptide in the chicken heart. Immunoreactive cells, both in the atrial and ventricular walls, were identified by electron microscopy, and electron-dense granules in the atrial and ventricular cardiocytes were revealed to be storage sites of the peptide. The electron-dense material, thought to be the peptide, was found in the sarcoplasmic reticulum, and it is suggested that a secretory pathway of the peptide through the latter to extracellular space, may be present, in addition to an exocytotic one. |
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Keywords: | Atrial natriuretic peptide (ANP) Chicken natriuretic peptide (chANP) Atrial-specific granule Sarcoplasmic reticulum Immunohistochemistry Domestic fowl (Aves Phasianiformes) |
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