Biogenic amines in the guinea pig endocrine pancreas. |
| |
Authors: | Y Cetin |
| |
Affiliation: | Abt. Anatomie 1, Medizinische Hochschule Hannover, Federal Republic of Germany. |
| |
Abstract: | Pancreata of guinea-pigs were investigated for the presence and cellular distribution of biogenic amines. Out of the established endocrine cell types only insulin (B-) cells contained immunoreactivity for serotonin and noradrenaline. However, the B-cells' content of both amines was quite variable. Serotonin was also confined to enterochromaffin (EC-) cells. No immunoreactivity for dopamine or histamine was present in any islet cell. Treatment of guinea-pigs with Ro-4-4602 led to a marked decrease of serotonin and noradrenaline in pancreatic endocrine cells. The present findings suggest that serotonin and noradrenaline are involved in the function of the endocrine pancreas, particularly of islet B-cells. |
| |
Keywords: | |
|
|