Peptide selection by class I molecules of the major histocompatibility complex |
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Authors: | Elliott T Smith M Driscoll P McMichael A |
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Affiliation: | Molecular Immunology Group, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK. |
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Abstract: | Class I molecules of the major histocompatibility complex (MHC) bind peptides derived from cytoplasmic proteins. Comparison of over 100 such peptides reveals the importance of the carboxy-terminal residue in selective binding. Recent evidence implicates the proteases and transporters of the processing pathway in providing peptides with the correct residues at the carboxyl terminus. |
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