Effect of intraventricularly injected ricin on protein synthesis in rat brain |
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| Authors: | Paola Strocchi F Novello N Montanaro F Stirpe |
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| Institution: | (1) Istituto di Farmacologia dell' Università di Bologna, I-40126 Bologna, Italy;(2) Istituto di Patologia Generale dell' Università di Bologna, I-40126 Bologna, Italy;(3) Mailman Research Center, McLean Hospital, 02178 Belmont, Massachusetts;(4) Harvard Medical School, Boston, Massachusetts |
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| Abstract: | Ricin, a protein from the seeds ofRicinus communis which inhibits protein synthesis by eukaryotic ribosomes, is highly toxic when injected intraventricularly to rats, the LD50 being 0.241  g/rat at 72 hr and 0.084 g/rat at 7 days. Poisoned animals showed signs of central depression; they did not die before 20 hr of intoxication. Incorporation of amino acids in vivo into brain total protein and into brain ribosomes was impaired, as was protein synthesis in vitro by microsomes isolated from the brain of poisoned rats. |
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