Peroxidation of Phospholipids Promoted by Myeloperoxidase |
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| Authors: | Gunnar Carlin Rickard Djurs ter |
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| Institution: |
a Department of Experimental Medicine, Uppsala, Sweden |
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| Abstract: | Myeloperoxidase was found to promote peroxidation of phospholipids under acidic conditions in the presence of hydrogen peroxide and iodide ions The peroxidation was markedly enhanced by pyrophosphate-chelated ferric iron and was inhbited by desferrioxamine and superoxide dismutase. This observation adds lipid peroxidation to the oxidative damage caused by myeloperoxidase, which is a phagocytic cell enzyme involved in phapocyte-mediated cell destruction. |
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| Keywords: | Myeloperoxidase lipid peroxidation superoxide dismutase hypoiodite-mediated peroxidation SOD-inhibited peroxidation |
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