Scaffolds for Skeletal Regeneration |
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Authors: | Ung-il Chung Keiji Itaka Nobuhiro Nishiyama Tsuyoshi Takato Hiroshi Kawaguchi Kozo Nakamura Kazunori Kataoka |
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Institution: | (1) The University of Tokyo Graduate Schools of Engineering and Medicine, 7-3-1 Hongo, Bunkyo-ku Tokyo, 113-0033, Japan |
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Abstract: | Although current treatment modalities for bone defects include autograft, allograft, and artificial bone substitutes, they
have problems concerning invasiveness, safety, and performance, respectively, calling for development of innovative artificial
bones with better handling and mechanical strength, better control of external and internal structures, and better biodegradability
and osteo-inductive ability. We propose to fabricate novel high-performance artificial bones using 3D inkjet printer based
on the image data of bone defect/deformity. Shape precisely fitting to the defect/deformity, internal structure facilitating
cell invasion, and good biodegradability are achieved. Bioactive substances can be incorporated by printing in combination
with drug delivery system to induce bone regeneration at the desired locations. These osteo-inductive artificial bones will
help efficiently treat various types of bone defect/deformity in a less invasive and safe manner. |
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Keywords: | bone regeneration 3D printer drug delivery system intelligent device |
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