Mutation and inhibition studies of mevalonate 5-diphosphate decarboxylase |
| |
| Authors: | Qiu Yongge Gao Jinbo Guo Fei Qiao Yuqin Li Ding |
| |
| Institution: | Department of Biology and Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong SAR, PR China. |
| |
| Abstract: | Mevalonate 5-diphosphate decarboxylase plays an important role in regulating cholesterol biosynthesis, which was studied through incubation with various synthetic substrate analogs and characterization of mutated enzymes. The results are potentially useful for further developing inhibitors that block the mevalonate pathway which is a drug target for treating cardiovascular disease and cancer. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
