A genetic and molecular analysis of P-induced mutations at the glucose-6-phosphate dehydrogenase locus in Drosophila melanogaster |
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Authors: | Debra Nero Nathaniel Bowditch Sally Pickert Ross J. MacIntyre |
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Affiliation: | (1) Department of Genetics and Developmental, Bradfield Hall, Cornell University, 14853 Ithaca, NY, USA;(2) Present address: Centre for Molecular Biology and Medicine, Monash University, 3168 Clayton, Victoria, Australia |
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Abstract: | Summary We examined P factor induced mutations of the Zw gene of Drosophila melanogaster in order to learn more about the site specificity of such mutations. Approximately 70000 chromosomes were screened using a powerful positive selection scheme. As only two mutants were discovered, Zw is a cold spot for transposable element insertion. One mutation involved a complex P element associated chromosomal rearrangement which was used to define the orientation of the gene with respect to the centromere of the X chromosome. The second mutation was either a simple, non-dysgenically induced point mutation or a very unstable insertion. |
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Keywords: | Drosophila melanogaster Glucose-6-phosphate dehydrogenase P element associated mutation Chromosomal rearrangement |
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