Contrasting effects of early and late orchiectomy on hypertension and renal disease in fawn-hooded rats |
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| Authors: | N Gilboa A M Magro Y Han U H Rudofsky |
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| Affiliation: | 1. Wadsworth Center for Laboratories and Research, New York State Department of Health, Albany, NY 12201, USA;2. Department of Pediatrics, Albany Medical College, Albany, NY 12208, USA;1. Department of Endocrinology, VU University Medical Center, Amsterdam, The Netherlands;2. Department of Endocrinology, Ghent University Hospital, Ghent, Belgium;3. Department of Medical Psychology, VU University Medical Center, Amsterdam, the Netherlands;4. Center for Sexology and Gender, Ghent University Hospital, Ghent, Belgium;5. Sexual Medicine and Andrology Unit, Department of Experimental, Clinical and Biomedical Sciences, University of Florence, Florence, Italy;6. Department of Obstetrics and Gynaecology, VU University Medical Center;7. Department of Endocrinology, Oslo University Hospital, Oslo, Norway;1. Spinal Cord & Brain Injury Research Center, University of Kentucky, Lexington, KY, United States;2. Department of Neuroscience, University of Kentucky, Lexington, KY, United States;3. Sanders Brown Center on Aging, University of Kentucky, Lexington, KY, United States;4. Department of Nutrition and Pharmacology, University of Kentucky, Lexington, KY, United States;1. Copenhagen Prostate Cancer Center, Department of Urology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark;2. Regional Cancer Centre Uppsala Örebro, Uppsala University Hospital, Uppsala, Sweden;3. Cancer Epidemiology Group, School of Medicine, Division of Cancer Studies, King''s College London, London, UK;4. Department of Oncology, Institute of Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden;5. Department of Urology, SUS Malmö, Region Skåne, Malmö, Sweden;6. Epidemiology Unit, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden;7. CLINTEC-department, Karolinska Institutet, Stockholm, Sweden;8. Department of Urology, Ryhov Hospital, Jönköping, Sweden;9. Department of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden;10. Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University Hospital, Umeå, Sweden |
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| Abstract: | Fawn-hooded (FH) rats, primarily males, develop spontaneous low-renin hypertension associated with reduced urinary excretion of kallikrein as early as 2 months of age, followed by progressive glomerular sclerosis and proteinuria as early as 3 months of age. In the present study we determined the effects of early (5-7 weeks) or late (5 months) orchiectomy on the blood pressure and nephropathy of FH rats, compared to sham-operated (control) FH males. Early orchiectomy reduced significantly the progression of glomerular sclerosis and of proteinuria and ameliorated the hypertension but had no significant effect on excretion of urinary kallikrein. Late orchiectomy, in contrast, had no significant effect on the progression of glomerular sclerosis or proteinuria but did significantly reduce the blood pressure and marginally increase the excretion of urine kallikrein. These results suggest that (a) male sex hormones may play a role in the pathogenesis of hypertension and nephropathy in the FH rats and (b) renal disease in this strain progresses in spite of improvement in blood pressure. |
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