Intestinal leucine aminopeptidase and alkaline phosphatase: Genetic regulation and development in mice |
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Authors: | Mary-Fleming Finlay Laryssa McCloud |
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Institution: | (1) Benedict College, 29204 Columbia, South Carolina |
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Abstract: | Intestinal and serum leucine aminopeptidase (LAP) and alkaline phosphatase (AKP) were characterized by electrophoresis for
eight inbred strains of laboratory mice. Intestinal LAP and AKP of adult mice were expressed concordantly within strains,
as banded or diffuse, and concordantly for rate of migration within strains that had diffuse isozymes. All strains, except
DD/S, had a single band of serum LAP and a single, diffuse zone of serum AKP. DD/S had a double band of serum LAP as well
as isozymes of intestinal LAP and AKP unlike those of other strains. All strains displayed similar, neuraminidase-sensitive
isozymes of intestinal LAP and of AKP prior to weaning, but after weaning there was marked sensitivity to neuraminidase only
in DD/S. In interstrain crosses, banded/diffuse, migration rate, and neuraminidase sensitivity were inherited as independent
autosomal traits, with indications of variable penetrance and genetic interaction.
Support was provided by NIH Grant RR08117. |
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Keywords: | alkaline phosphatase leucine aminopeptidase intestine electrophoresis mouse sialation |
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