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Large-scale analysis of protein expression changes in human keratinocytes immortalized by human papilloma virus type 16 E6 and E7 oncogenes |
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| Authors: | Mark A Merkley Ellen Hildebrandt Robert H Podolsky Hilal Arnouk Daron G Ferris William S Dynan Hubert Stöppler |
| Institution: | (1) Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA, USA;(2) Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta, GA, USA;(3) Department of Obstetrics and Gynecology, Medical College of Georgia, Augusta, GA, USA;(4) Department of Family Medicine, Medical College of Georgia, Augusta, GA, USA;(5) Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA;(6) Division of Hematology/Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA |
| Abstract: | BackgroundInfection with high-risk type human papilloma viruses (HPVs) is associated with cervical carcinomas and with a subset of head and neck squamous cell carcinomas. Viral E6 and E7 oncogenes cooperate to achieve cell immortalization by a mechanism that is not yet fully understood. Here, human keratinocytes were immortalized by long-term expression of HPV type 16 E6 or E7 oncoproteins, or both. Proteomic profiling was used to compare expression levels for 741 discrete protein features. |
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