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Trichostatin A treatment of cloned mouse embryos improves constitutive heterochromatin remodeling as well as developmental potential to term |
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| Authors: | Walid E Maalouf Zichuan Liu Vincent Brochard Jean-Paul Renard Pascale Debey Nathalie Beaujean Daniele Zink |
| Affiliation: | 1. INRA, UMR 1198 Biologie du Développement et Reproduction, F-78350, Jouy en Josas, France 2. Department Biologie II, LMU München, Grosshaderner Str. 2, 82152, Planegg-Martinsried, Germany 3. QMRI, University of Edinburgh, 47 Little France Crescent, Edinburgh, UK 4. State Key Lab of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100080, PR China 5. UMR 5153 CNRS MNHN, Muséum national d'Histoire naturelle, CP26, 57 Rue Cuvier, 75231, Paris Cedex 05, France 6. Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, #04-01, 138669, Singapore, Singapore |
| Abstract: | BackgroundGenome reprogramming in early mouse embryos is associated with nuclear reorganization and particular features such as the peculiar distribution of centromeric and pericentric heterochromatin during the first developmental stage. This zygote-specific heterochromatin organization could be observed both in maternal and paternal pronuclei after natural fertilization as well as in embryonic stem (ES) cell nuclei after nuclear transfer suggesting that this particular type of nuclear organization was essential for embryonic reprogramming and subsequent development. |
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