Inhibitory effect of tea polyphenols on histamine and leukotriene B4 release from rat peritoneal exudate cells |
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Authors: | Noritaka Matsuo Koji Yamada Kouhei Yamashita Kentaro Shoji Mitsuo Mori Michihiro Sugano |
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Affiliation: | (1) Laboratory of Food Science, Department of Food Science and Technology, Kyushu University School of Agriculture 46-09, 6-10-1 Hakozaki, Higashi-ku, 812-81 Fukuoka, Japan |
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Abstract: | Summary The effect of tea polyphenols on the release of chemical mediators, histamine and leukotriene B4 (LTB4), from rat peritoneal exudate cells (PEC) was studied. Among polyphenols, (−)-epigallocatechin gallate (EGCG) most strongly inhibited the histamine release from the cells stimulated with a calcium ionophore, A23187 or compound 48/80. Though (+)-catechin (C) and (−)-epicatechin (EC) had no effect, (−)-epigallocatechin (EGC) and (−)-epicatechin gallate (ECG) moderately inhibited the histamine release. Similarly, EGCG, ECG, and EGC inhibited LTB4 release from PEC, whereas C and EC were not effective. The magnitude of the inhibitory effect on the release of these mediators of tea polyphenols was in the order of EGCG>ECG>EGC. These results indicated an important role of the triphenol structure in the inhibitory activity. Therefore, the possible antiallergic effect of tea polyphenols can be expected. |
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Keywords: | mast cell polyphenol histamine leukotriene |
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