Nuclear ribonucleoproteins recognized by human antinuclear antibodies in retrovirus-infected cells |
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| Authors: | J P Barque P Yeni L Peraudeau F Danon C J Larsen |
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| Institution: | 1. Laboratoires de Pharmacologie Experimentale et d''Immunochimie-Immunopathologie. U-108 Hôpital Saint-Louis - 2 Place du Dr. Fournier - 75010 Paris - France.;2. Laboratoire d''Oncologie et d''Immunologie du CNRS (L.O.I) - Hôpital Saint-Louis - 2 Place du Dr. Fournier - 75010 Paris - France. |
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| Abstract: | Antibodies present in sera of patients with auto immune diseases (systemic Lupus erythematosus, mixed connective tissue disease) were used to react with nuclear ribonucleoproteins (HnRNPs) from normal cells and cells infected with retroviruses. Only antibodies directed against Sm and RNP antigens precipitated particles with definite spectra of small nuclear RNAs (SnRNA) and proteins. No difference could be found between infected and uninfected cells, suggesting that virus replication is dependent on normal cellular fonctions. |
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