Increase of Lipid Hydroperoxides in Tissues of Vitamin E-Deficient Rats |
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| Authors: | Sadako Tokumaru Ritsu Ogino Ayako Shikomoto Hiroshi Iguchi Shosuke Kojo |
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| Affiliation: | a Department of Food Science and Nutrition, Nara Women's University, Nara 630, Japanb Department of Public Health, Faculty of Medicine, Kyoto University, Kyoto 606, Japan |
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| Abstract: | The level of lipid hydroperoxides was determined by a newly developed method in rat tissues of vitamin E deficiency, which was a good in viuo model of enhanced radical reactions. In the heart, lung and kidney, the level of lipid hydroperoxides increased significantly as early as 4 weeks after feeding on a tocopherol-deficient diet compared with that of the control group. After 8 weeks of the deficiency, similar results were obtained. These results indicate that the lipid hydroperoxide is available as an extremely sensitive indicator of lipid peroxidation in these organs, because it takes several months to detect manifestations of the vitamin deficiency based on conventional indices. |
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| Keywords: | Vitamin E deficiency tocopherol hydroperoxide vitamin E peroxide lipid hydroperoxide |
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