Pathogenicities and GP43kDa gene of three Paracoccidioides brasiliensis isolates originated from a nine-banded armadillo Dasypus novemcinctus ) |
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Authors: | Sano Ayako |
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Institution: | Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Japan. |
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Abstract: | We studied three different isolates of Paracoccidioides brasiliensis obtained from the mesenteric lymph node (D3LY1), the
spleen (D3S1) and the liver (D3LIV1) of the same armadillo ( Dasypus novemcinctus ).Pulmonal inflammatory area was evaluated
by intravenous inoculation of 106 yeast cells of each isolates in young, male, ddY mice. Moreover, the partial sequence of GP43kDa gene of P. brasiliensis
was analyzed. The lung inflammatory area was greater in animals inoculated with isolate D3S1. The partial sequence of GP43kDa
gene indicated that isolate D3S1 is different from isolates D3LY1 and D3LIV1. This study suggested that the same armadillo
might be susceptible to multiple P. brasiliensis isolates simultaneously.
This revised version was published online in August 2006 with corrections to the Cover Date. |
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Keywords: | armadillo GP43kDa gene Paracoccidioides brasiliensis pathogenicity |
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