Transformation of the proteasome with age-related macular degeneration |
| |
Authors: | Ethen Cheryl M Hussong Stacy A Reilly Cavan Feng Xiao Olsen Timothy W Ferrington Deborah A |
| |
Institution: | Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA. |
| |
Abstract: | The proteasome mediates pathways associated with oxidative stress and inflammation, two pathogenic events correlated with age-related macular degeneration (AMD). In human donor eyes corresponding to four stages of AMD, we found the proteasomal chymotrypsin-like activity increased in neurosensory retina with disease progression. Increased activity correlated with a dramatic increase in the inducible subunits of the immunoproteasome, which was not due to an increase in CD45 positive immune cells in the retina. The novel observation of proteasome transformation may reflect retinal response to local inflammation or oxidative stress with AMD. |
| |
Keywords: | 20S Proteasome Chymotrypsin-like activity Immunoproteasome Age-related macular degeneration |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|