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General synthesis of alpha-substituted 3-bisaryloxy propionic acid derivatives as specific MMP inhibitors |
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| Authors: | Chollet A M Le Diguarher T Murray L Bertrand M Tucker G C Sabatini M Pierré A Atassi G Bonnet J Casara P |
| Institution: | Institut de Recherches Servier, Croissy sur Seine, France. |
| Abstract: | Modulations of alpha and aryl substitutions on 3-aryloxy propionic acid hydroxamates led to novel and potent inhibitors of MMP-2,3,9 and 13, and selectivity versus MMP-1. |
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