Determinants of uterine aging: lessons from rodent models |
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| Authors: | ShuangBo Kong Shuang Zhang YongJie Chen WeiXiang Wang BingYan Wang Qi Chen EnKui Duan HaiBin Wang |
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| Affiliation: | 1. State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China
2. Graduate University of Chinese Academy of Sciences, Beijing, 100039, China
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| Abstract: | The uterus is an indispensable organ for the development of a new life in eutherian mammals. The female mammalian reproductive capacity diminishes with age. In this respect, the senescence of uterine endometrium is convinced to contribute to this failure. This review focuses on the physiological function of the uterus and the related influence of aging mainly in rodent models. A better understanding of the underlying mechanisms governing the process of uterine aging is hoped to generate new strategies to prolong the reproductive lifespan in humans. |
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