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Single-nucleotide polymorphisms and haplotype of <Emphasis Type="Italic">CYP2E1</Emphasis>gene associated with systemic lupus erythematosus in Chinese population |
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| Authors: | Ling-hong Liao Hao Zhang Man-Po Lai Shun-Le Chen Madeline Wu Nan Shen |
| Institution: | (1) The Research Base of TCM Syndrom, Fujian University of Traditional Chinese Medicine, Huatuo Road No.1, Fuzhou, 350108, PR China;(2) Department of Biology and Center for Cancer Research, Hong Kong University of Science and Technology, Clear Water Bay Road No.1, Hong Kong, PR China;(3) Joint Molecular Rheumatology Laboratory of Institute of Health Sciences and Shanghai Ren Ji Hospital, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai JiaoTong University School of Medicine, 145 Shan Dong Middle Road, Shanghai, 200001, PR China |
| Abstract: | IntroductionCytochrome P-450 2E1 (CYP2E1) is an important member of the CYP superfamily, which is involved in the metabolism and activation of many low molecular weight toxic compounds. We tried to investigate the possible association of CYP2E1 tag single nucleotide polymorphisms (SNPs) with susceptibility to systemic lupus erythematosus (SLE) in a Chinese Han population. |
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