Persistent directional cell migration requires ion transport proteins as direction sensors and membrane potential differences in order to maintain directedness |
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| Authors: | Nurdan Özkucur Srikanth Perike Priyanka Sharma Richard HW Funk |
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| Institution: | (1) Department of Anatomy, Medical Faculty Carl Gustav Carus, Technical University of Dresden, Dresden, Germany |
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| Abstract: | Background Ion transport proteins generate small electric fields that can induce directional cell motility; however, little is known
about their mechanisms that lead to directedness. We investigated Na, K-ATPase (NaKA) and Na+/H+ exchanger isoforms (NHE1
and 3) in SaOS-2 and Calvarial osteoblasts, which present anode- and cathode- directed motility, during electrotaxis. |
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