The role of Eag and HERG channels in cell proliferation and apoptotic cell death in SK-OV-3 ovarian cancer cell line期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

The role of Eag and HERG channels in cell proliferation and apoptotic cell death in SK-OV-3 ovarian cancer cell line

Authors:	Viren?Asher author-information" > author-information__contact u-icon-before" > mailto:Viren.Asher@nottingham.ac.uk" title=" Viren.Asher@nottingham.ac.uk" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author,Averil?Warren,Robert?Shaw,Heidi?Sowter,Anish?Bali,Raheela?Khan

Affiliation:	(1) School of Graduate Entry Medicine and Health Royal Derby Hospital, Uttoxeter Road, DE22 3DT Derby, UK;(2) Department of Gynaecological Oncology Royal Derby Hospital, Uttoxeter Road, DE22 3NE Derby, UK;(3) University of Derby, Kedleston road, Derby, UK

Abstract:	Background The voltage gated potassium (K⁺) channels Eag and HERG have been implicated in the pathogenesis of various cancers, through association with cell cycle changes and programmed cell death. The role of these channels in the onset and progression of ovarian cancer is unknown. An understanding of mechanism by which Eag and HERG channels affect cell proliferation in ovarian cancer cells is required and therefore we investigated their role in cell proliferation and their effect on the cell cycle and apoptosis of ovarian cancer cells.

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