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Lateral gene transfer of streptococcal ICE element RD2 (region of difference 2) encoding secreted proteins |
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| Authors: | Izabela Sitkiewicz Nicole M Green Nina Guo Laurent Mereghetti James M Musser |
| Institution: | 1.Center for Molecular and Translational Human Infectious Diseases Research, The Methodist Hospital Research Institute, and Department of Pathology,The Methodist Hospital,Houston,USA;2.Department of Epidemiology and Clinical Microbiology,National Medicines Institute,Warszawa,Poland;3.Université Fran?ois-Rabelais, Faculté de Médecine, EA 3854 "Bactéries et Risque Materno-Foetal",Tours,France |
| Abstract: | BackgroundThe genome of serotype M28 group A Streptococcus (GAS) strain MGAS6180 contains a novel genetic element named Region of Difference 2 (RD2) that encodes seven putative secreted extracellular proteins. RD2 is present in all serotype M28 strains and strains of several other GAS serotypes associated with female urogenital infections. We show here that the GAS RD2 element is present in strain MGAS6180 both as an integrative chromosomal form and a circular extrachromosomal element. RD2-like regions were identified in publicly available genome sequences of strains representing three of the five major group B streptococcal serotypes causing human disease. Ten RD2-encoded proteins have significant similarity to proteins involved in conjugative transfer of Streptococcus thermophilus integrative chromosomal elements (ICEs). |
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